kolblab.org

Kolb Lab Heisenberg DFG

Networks

The Kolb Lab is located at the Department of Pharmaceutical Chemistry at Philipps-Universität Marburg.

We are a member lab of GLUE,
the Priority Program 2363 "Molecular Machine Learning",
SYNMIKRO,
the transregional collaborative research centre 81 (SFB/Transregio81),
and DRUID.
We are also part of ERNEST, the "European Research Network on Signal Transduction".
Together with the Selent and Bouvier labs, we are investigating biased ligands of the 5-HT2A receptor in the context of the ERANET NEURON project PSYBIAS. Funding is provided by the Federal Ministry of Education and Research under grant number 01EW1909.



The lab was deeply involved in COST Action CM1207 "GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network"
and part of SynChemBio.
The lab started through the generous funding provided within the DFG's Emmy Noether Programme. Emmy Noether DFG
[en][de]

Research interests

Docking
Word cloud generated with wordart.com from publication abstracts.

Small molecules are frequently used both in Nature and therapeutically to modulate the activity of the protein they bind to. Yet, many aspects of small-molecule:protein interactions are surprisingly poorly understood. For instance, ligand polypharmacology, i.e. binding to multiple proteins, often comes as a surprise, although it is frequently precisely the reason for a drug's efficacy or its side effects. On the protein side, a point mutation in the binding site, although only a small change, can abolish drug binding, leading to resistance. Thus, it is highly relevant to develop a comprehensive understanding of small-molecule:protein interaction profiles in molecular detail and correlate these profiles with signaling and metabolic pathways.

Our main tool is small molecule docking, but we also use chemoinformatic approaches and molecular dynamics. The research spans method development, basic research and applications. Currently the investigations deal with kinases and G protein-coupled receptors (GPCRs).


Publications

Most recent:
54 The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites.
Janik B. Hedderich, Margherita Persechino, Katharina Becker, Franziska M. Heydenreich, Torben Gutermuth, Michel Bouvier, Moritz Bünemann, Peter Kolb
Nat. Commun. 2022, 13, 2567. [pdf]
53 Community guidelines for GPCR ligand bias: IUPHAR review 32.
Peter Kolb†,*, Terry Kenakin†,*, Stephen P. H. Alexander, Marcel Bermudez, Laura M. Bohn, Christian S. Breinholt, Michel Bouvier, Stephen J. Hill, Evi Kostenis, Kirill A. Martemyanov, Richard R. Neubig, H. Ongun Onaran, Sudarshan Rajagopal, Bryan L. Roth, Jana Selent, Arun K. Shukla, Martha E. Sommer, David E. Gloriam*
Br. J. Pharmacol. 2022, 179, 3651-3674. [pdf]
52 Disentangling bias between Gq, GRK2 and arrestin3 recruitment at the M3 muscarinic acetylcholine receptor.
Anja Flöser, Katharina Becker, Evi Kostenis, Gabriele König, Cornelius Krasel, Peter Kolb*, Moritz Bünemann*
eLife 2021, 0:e58442. [pdf]
full list

Lab members

Viviane Corrêa Santos [Former Guest Scientist]
Matthäus Drabek [Graduate Student]
Anja Flöser [Former Graduate Student]
Janik Hedderich [Graduate Student]
Jonas Kammertöns [Graduate Student]
Peter Kolb [Principal Investigator]
Victor Lim [Graduate Student]
Lea Löffler [Former Student Researcher]
Stefania Monteleone [Former Postdoc]
Maria Giovanna Papadopoulos [Graduate Student]
Margherita Persechino [Graduate Student]
Naiá Porã Santos [Former Intern]
Magdalena Scharf [Former Graduate Student]
Johanna Senst [Former Graduate Student]
Corey Taylor [Former Graduate Student]
Not in picture:
Frank Balzer [IT Administrator]
Pascal Büch [Intern]
Steffi Dörr [Technician Molecular Biology]
Linn Evenseth [Postdoc]
Hans-Dieter Gerber [Technician Medicinal Chemistry]
Franziska Giese [Student Researcher]
Shiva Mohajerani [Student Researcher]
Fiona Morhard [Student Researcher]
Anja Moser [Assistant]
Jan-Niklas Pütz [Student Researcher/MOS]
Klaus Reuter [apl Professor]
Hannes Schihada [Postdoc]
Aida Shahraki [Postdoc]
Jamal Shamsara [Postdoc Core Facility]

Teaching

We are involved in lectures and lab courses in Pharmaceutical Chemistry. Moreover, we accept students in the Chemistry and Pharmacy curricula for internships. Students with a keen interest in computation, chemistry, and biochemistry and their application to pharmaceutical questions are accepted for B.Sc., M.Sc., and Ph.D. theses (see also below, "Joining the lab").


Scubidoo & Pingui


PrenDB


Daim – a program to generate fragments


Joining the Lab




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